-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, BuE2VVrFr088VfRHX3evr1vUVyytEIin6ZbLLYpJTq79K3Li3+uh3K4ZOj359THI 1cvo7gkBplWK+ECddJyD6Q== 0001079817-05-000014.txt : 20050215 0001079817-05-000014.hdr.sgml : 20050215 20050214184100 ACCESSION NUMBER: 0001079817-05-000014 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20050215 DATE AS OF CHANGE: 20050214 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: EPIX Pharmaceuticals, Inc. CENTRAL INDEX KEY: 0001027702 STANDARD INDUSTRIAL CLASSIFICATION: IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835] IRS NUMBER: 043030815 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G SEC ACT: 1934 Act SEC FILE NUMBER: 005-52847 FILM NUMBER: 05613660 BUSINESS ADDRESS: STREET 1: 71 ROGERS ST CITY: CAMBRIDGE STATE: MA ZIP: 02142-1118 BUSINESS PHONE: 6172506000 MAIL ADDRESS: STREET 1: 71 ROGERS ST CITY: CAMBRIDGE STATE: MA ZIP: 02142-1118 FORMER COMPANY: FORMER CONFORMED NAME: EPIX MEDICAL INC DATE OF NAME CHANGE: 19961129 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: BROWN INVESTMENT ADVISORY & TRUST CO CENTRAL INDEX KEY: 0001079817 IRS NUMBER: 000000000 STATE OF INCORPORATION: MD FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: 901 SOUTH BOND STREET STREET 2: SUITE 400 CITY: BALTIMORE STATE: MD ZIP: 21231-3340 BUSINESS PHONE: 4105375400 MAIL ADDRESS: STREET 1: 901 SOUTH BOND STREET STREET 2: SUITE 400 CITY: BALTIMORE STATE: MD ZIP: 21231-3340 SC 13G 1 epix12312004.txt BROWN ADVISORY 13G4Q04 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 EPIX Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Par Value $.01) (Title of Class of Securities) 26881Q101 (CUSIP Number) 12/31/04 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [X] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) Check the following box if a fee is being paid with this statement [ ]. A fee is not required only if the filing person: (1) has a previous statement on file reporting beneficial ownership of more than five percent of the class of securities described in Item 1; and (2) has filed no amendment subsequent there to reporting beneficial ownership of five percent or less of such class. (See Rule 13d-7). The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). 1. NAME OF REPORTING PERSONS. I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Brown Advisory Holdings Incorporated ("BAHI") 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) [ ] (b) [ ] 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION BAHI is a Maryland Corporation. 5 SOLE VOTING POWER 972187 shares NUMBER OF SHARES BENEFICIALLY 6 SHARED VOTING POWER 0 shares OWNED BY EACH REPORTING 7 SOLE DISPOSITIVE POWER 1196076 shares PERSON WITH 8 SHARED DISPOSITIVE POWER 11200 shares 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1207276 shares 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES [ ] 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.2% 12. TYPE OF REPORTING PERSON BAHI - HC Item 1(a). Name of Issuer: EPIX Pharmaceuticals, Inc. Item 1(b). Address of Issuer's Principal Executive Offices: 161 First Street, Cambridge, MA 02142 Item 2(a). Name of Person Filing: BAHI Item 2(b). Address of Principal Business Office: 901 South Bond Street, Suite 400 Baltimore, Maryland 21231 Item 2(c). Citizenship: BAHI is a Maryland Corporation. Item 2(d). Title of Class of Securities: Common Stock of ($.01 par) of EPIX Pharmaceuticals, Inc. Item 2(e). CUSIP Number: 26881Q101 Item 3. If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b), check whether the person filing is a: (g) [x] A parent holding company or control person in accordance with section 240.13d-1(b)(1)(ii)(G) Item 4. Ownership: (a) Amount of Beneficially Owned: 1207276 shares (b) Percent of Class: 5.2% (c) Number of shares as to which such person has: (i) Sole power to vote or to direct the vote: 972187 shares (ii) Shared power to vote or to direct the vote: 0 shares (iii) Sole power to dispose or to direct the disposition of: 1196076 shares (iv) Shared power to dispose or to direct the disposition of: 11200 shares Item 5. Ownership of Five Percent or Less of a Class. Not applicable Item 6. Ownership of More than Five Percent on Behalf of Another Person. The securities as to which this Schedule is filed by BAHI, in its capacity as a parent holding company, are as follows: 263,211 shares, or 1.1% of the total shares outstanding of EPIX Pharmaceuticals, Inc., owned by clients of Brown Investment Advisory and Trust Company ("BIATC"), a Bank as defined in Section 3(a)(6) of the Act; and 944,065, or 4.1% of the total shares outstanding of EPIX Pharmaceuticals, Inc., owned by clients of Brown Investment Advisory Incorporated, an Investment Advisor registered under section 203 of the Investment Advisers Act of 1940 and a wholly-owned subsidiary of BIATC. Those clients have the right to receive, or the power to direct the receipt of, dividends from, or the proceeds from the sale of, such securities. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person. This Schedule is being filed pursuant to Rule 13d-1(b)(1)(ii)(G). Refer to Exhibit A. Item 8. Identification and Classification of Members of the Group. Not applicable Item 9. Notice of Dissolution of Group. Not applicable Item 10. Certification. By signing below I certify that to the best of my knowledge and belief, the securities referred to above were acquired in the ordinary course of business and were not acquired for the purpose of and do not have the effect of changing or influencing the control of the issuer of such securities and were not acquired in connection with or as a participant in any transaction having such purpose or effect. Signature: After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: As of December 31, 2004 Signature: Brown Advisory Holdings Incorporated By: /S/ Christopher P. Laia Title: Secretary Joint Filing Agreement ---------------------------- Each party signing below agrees that this statement is submitted as a joint filing on behalf of the undersigned. Date: As of December 31, 2004 Signature: Brown Investment Advisory and Trust Company By: /S/ Patrick Ventura Title: Principal Date: As of December 31, 2004 Signature: Brown Investment Advisory Incorporated By: /S/ Patrick Ventura Title: Principal Exhibit A Pursuant to the instructions in Item 7 of this Schedule 13G, the identity and the Item 3 classification of the relevant subsidiaries are: BIATC, a Bank as defined in Section 3(a)(6) of the Act; and Brown Investment Advisory Incorporated, an Investment Advisor registered under section 203 of the Investment Advisers Act of 1940 and a wholly-owned subsidiary of BIATC. -----END PRIVACY-ENHANCED MESSAGE-----